11 Chronic pain is defined as persistent or intermittent pain that lasts for more than three months. 10 Chronic pain may accelerate frailty progression due to neuroinflammation. The correlation between chronic pain and frailty was significant in older adults. 9 Given the high prevalence of frailty in older cancer patients and the negative health outcomes that frailty can lead to, it is particularly important to research how to prevent and manage frailty in elderly cancer patients. 8 Various studies have shown that frailty is strongly associated with hospitalization, disability, mortality, etc. 7 According to previous studies, the prevalence of cancer frailty in the elderly has been found to range from 6% to 86%, with a median of 42%. The frail state is influenced by a range of variables, leading to increased risks of adverse outcomes. 6 Frailty is a dynamic change process that affects individuals with one or more declines in functioning (physical, psychological, and social). These manifestations often occur simultaneously and accumulate over time, leading to frailty. Broadly, the aging process is accompanied by a variety of functional impairments, such as pain, fatigue, cognitive impairment, and so on. 5 Cancer treatments accelerate biological aging. 3 The incidence of cancer in elderly patients accounted for 46.29%, 4 and then the premature death rate of cancer in Nantong have ranked first among chronic diseases. 2 According to “Nantong Seventh Population Census Bulletin”, 30.01% of the population in Nantong was over 60 years old, and the city as a whole has entered a stage of heavy aging.
1 Moreover, the statistics in the SEER database showed, during 2015-2019, 82.46% of cancer cases occurred in older adults. According to the statistics, between 20, the combined incidence of cancer was 155.5 per 100,000 population in the United States.
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